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              ZؐίTָHarvey J. AlterMichael HoughtonCharles M. Rice_԰lFĶbһNͲ͸ײ_չ֮ǰlFͺ͸ײǰ~PIEѪԴԸײԟo͸ײİlFʾʣԸײIJʹ_lѪҺzyͿˎɞ@Nʷԁһο@˿͸ײϣ˔f˵

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              ͸һNѪҺı͸ײhepatitis C virus (HCV)µԺԇظس̶ȏijmܵpȼصĽKԼHCVȾˣ80]аYFYtcʽļԲԸכ]Ѕ^eҿܰʳʹƣSڻHCVȾҊİYƣͨͨ^û؏ʹõ^עԼܸȾݔѪОѪҺ¶
               

              ȫ͸ײȾrThe Polaris Observatory HCV Collaborators. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study. Lancet Gastroenterol Hepatol. 2017;2:161C76

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              Liu Z, Jiang Y, Yuan H, Fang Q, Cai N, Suo C, Jin L, Zhang T, Chen X. The trends in incidence of primary liver cancer caused by specific etiologies: Results from the Global Burden of Disease Study 2016 and implications for liver cancer prevention. J Hepatol. 2019 Apr;70(4):674-683. doi: 10.1016/j.jhep.2018.12.001. Epub 2018 Dec 11. PMID: 30543829.IHMEGBD
               
              HYоCIARCYϱ2018ȫΰ°l˔^84fΰµ˔s78fsһĸΰ°ll҇oȫc҇˘Oصļؓ
               
              ͵WdcF܊F꠴ǰϵy19902016g195Һ͵؅^ĸΰlģʽlFHBVȾȻ緶Ȍ¸ΰҪռȳ^40%ږ|ǵ؅^@һ^50%ڸձn¼ȇHCVnj¸ΰҪڰԼWƾԸΰtռ“ψFMһΰl׃څMзlFȫ򷶇HCVµĸΰl҂òȥҕ@}
               
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              2016桶͸׸ȾߵĺYoίָϡWHO

                HCV͵ȫֲWHO

              HCVImٰlչԏlM2014lһݡ͸׸ȾߵĺYoίָϡԁQֱÿˎDAAˎڸ׃HCVίʹ˂Կڷoˎmrg^̣ܣʸ90
               
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              ͸ײİlFʹBaruch Blumberg1976@ZؐWtWBaruch Blumberg͸˹˹YģFox Chase Cancer Centerͬ‚1967lF@N_lڙzyԓѪҺzyʽ1969l˵һҸ1981õFDA@ǵһN܉AY

              Baruch Blumbergʿ1976ZؐCY

              Baruch Blumbergˌ׸Եz׃dȤԲͬҵѪҺӱMеоlFһNصĵ|ԓ|CLڌ͸ײ⚤

              ͸׵ęzyίҲʼ܉ReԓĴ͸ײİlFЛQx

              @λƌWҌһoĕrgƌWHarvey J. AlterڇlоԺNIHRݔѪtWϵθ߼оTglF˱͸Michael Houghton1989ڼ၆һ\g˾rȡͻԵİlFCharles M.Ricetһֱ˷մW͸оĵĿƌWֱ͈2018߀һֱS

              քe@2020ZؐtWHarvey J. AlterMichael HoughtonCharles M. RiceԴRhoda Baer/National Institutes of Health, Richard Siemens/University of Alberta

              Harvey J. AlterMеݔѪPԸ׵ķоδ֪njԸ׵ijҊԭ1970AlterIһMƌWҰlFݔѪײocAͻBͲP“@ʾ˴δlFIJԭw

              Michael HoughtonʹδzyIJԁx͸ײ²M1980Michael HoughtoncλͬQui-Lim ChooGeorge KuoɞһReʽ͸ײQȾԪ@헹ٳ˱͸ײ\zyİlչʹtоˆT״܉Y靓ڻ

              SAlterʿHoughtonʿĹ@2000˹RtWо

              ʥ·˹AʢDWоTCharles M. RicetṩCCH͸ײCharles M. RiceԼָͬ͸ײMĩ˵һǰδ֪ą^@܌ƺҪ

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              Charles M. RiceʿĻƌWҌ@NҪļԓڌзxڄɣ𼲲@Що͸ײ_ؓ؟صġABײΨһȾԭԺоPҪĄģ

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              Vaccines 2019, 7(4), 204; https://doi.org/10.3390/vaccines7040204

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              Charles Riceͬ׫һо}顰Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virusؓ򲡶RNAĿҕֱ̽ÿ͸ײęCƣ201911°lڡs־

                

              Viruses 2019, 11(11), 1039; https://doi.org/10.3390/v11111039

              @ҪlīI

              Alter HJ, Holland PV, Purcell RH, Lander JJ, FeinstoneSM, Morrow AG, Schmidt PJ.
              Posttransfusion hepatitis after exclusion of commercial and hepatitis-B antigen-positive donors. Ann Intern Med. 1972; 77:691-699.
               
              Feinstone SM, Kapikian AZ, Purcell RH, Alter HJ, Holland PV. Transfusion-associated
              hepatitis not due to viral hepatitis type A or B. N Engl J Med. 1975; 292:767-770.
              Alter HJ, Holland PV, Morrow AG, Purcell RH, Feinstone SM, MoritsuguY. Clinical and
              serological analysis of transfusion-associated hepatitis. Lancet. 1975; 2:838-841.
               
              Alter HJ, Purcell RH, Holland PV, Popper H. Transmissible agent in non-A, non-B hepatitis. Lancet. 1978;1:459-463.
               
              Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA
              clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989; 244:359-362.
               
              Kuo G., ChooQL, AlterHJ, GitnickGL, Redeker AG, Purcell RH, Miyamura T, Dienstag JL, Alter CE, Stevens CE, Tegtmeier GE, Bonino F, Colombo M, Lee WS, Kuo C., Berger K, Shuster JR, Overby LR, BradleyDW, HoughtonM. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989; 244:362-364.
               
              Kolykhalov AA, Agapov EV, Blight KJ, Mihalik K, Feinstone SM, Rice CM. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science. 1997; 277:570-574.


               

              2020ZؐWtW

              Harvey J. Alter1935ڼ~s_˹شWtWԺ@tWWλ˹ʼotԺňDWtԺ܃ȿtWӖ1961lоԺNIHRچζشW˔Ȼ1969귵NIHRݔѪtWϵĸ߼оT

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              Charles M. Rice1952׸_TУSacramento1981ڼWԺ@òʿWλ19811985g˲ʿӖ1986ʥ·˹AʢDWtWԺоСM1995ɞʽ2001ԁһֱμ~s˷մWĽ20012018gһֱ˷մW͸оĵĿƌWcһֱSԓ

              ZؐίTͨJɻAƌWAƌW鮔ձʹõČHõ춨˻AͬһIĎλƌWҷǺܳҊȥӢƌWұ˵áؿPeter RatcliffeP֣William Kaelin͸׸÷Gregg SemenzalFwθ֪͑ˮƽļ@

               

              2019ZؐWtW

              Zؐ헰һöƺ1000fʣs111.8fԪĪ2019100fmͨ؛Ûԓī@lҰ׵¡ZؐAlfred Nobel124ǰµzٛ

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              ŒӢtڵ¡DLauder Brunton1867lFЧĽgʹʹ1890Zؐt]ʹίKˎrܽ^

               

              1998ZؐWtW

               

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              PڸZؐWtWϢԅ÷˹tWġZؐtW1901-2020
               

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