ţۃעҺ

              ˎƷʾ:

              ţۃעҺmڣƷmί˵ģ

              • ѪܣԣgPS׃ԣnAMD

              • Sˮ[DME

              PڰţۃעҺÙCЧˎmY÷ЧɰYע헼rϢZˎIˎBˎͬrĽՈ_xˎˎ ԃˎ

              ˎQ
              ͨQ: עҺ
              ӢQ: Aflibercept Intravitreous Injection
              ƷQ:

              ųɷ֡
              Գɷݞ鰢ͨ^ؽM DNA gЇ}ѳCHOK1 aںϵԓںϵѪ܃ƤLwVEGFRY 򣨼 VEGFR1 Ig2 ^ VEGFR2 Ig3 ^c IgG1 Fc YںϺγɵͬ Դwǵ

              oϞɽ 20cһˮcˮȻcǺעˮ

              Ԡ
              oɫSɫĵȝBҺ

              mY
              Ʒmί˵ģ

              • ѪܣԣgPS׃ԣnAMD

              • Sˮ[DME

              Ҏ
              40mg/ml,ÿƿɳȡwe0.1ml,ஔ4mg

              ÷
              ƷHwע

              ֻɾ߂Swע佛tע䱾Ʒ

              ѪܣԣgPS׃

              Ʒ] 2 mg ஔ 50 ΢

              Ʒίʽʼ 3 BmÿעһȻÿɂעһ עgڃȟoMбOy

              ʹñƷί 12 ֮ɸҕ/ʌWYLίg簴ίtoˎɌίrggLԾSַҕ/ʌWYĿǰ߀]Ĕ֧ڴoˎgrLóĽYՓ ҕ/ʌWYFtsίrgg

              ίt_Oyrgҿܱȼȶעrgl

              Sˮ[DME

              Ʒ] 2 mg ஔ 50 ΢

              Ʒίʽʼ 5 BmÿעһνoˎȻÿɂעһ עgڃȟoMбOy

              Ʒί 12 ºɸҕ/ʌWYLίg簴ίtoˎɌίrggLԾSַҕ/ʌWYĿǰ߀]Ĕ֧ڴoˎgrLóĽYՓҕ /ʌWYFtsίrgg

              ίt_Oyrgҿܱȼȶעrgl

              ҕͽʌWYʾߛ]Џ^mίЫ@tҪKֹί

              Ⱥ

              ܺ/Iܓp

              δܺ/IܓpĻЌTᘌƷ_չضо

              FДo@Щ{ƷԔҊˎW

              Ⱥ

              o⿼]75 qSˮ[DME껼ʹñƷĽ

              ͯc꣨18 q£

              δڃͯд_ƷİȫԺЧδڻѪܣԣnAMD DME ăȺʹ^Ʒ

              ɾ߂Swע佛ttW˜ʺPָψвwעһ횴_͟oʹþֲVVأ磺 Ƥw۲۱ʹþ۾Sͪ⣩]ʹgֲoogκ͟o_ߣ

              ĽĤ 3.5-4.0 mm ̎MˮƽMᘂwֱM벣wǻȻo豾Ʒ 0.05 mlmע䑪ڲͬĤλM

              wע̱֮OyߵۃȉǷm˵ıOyʩɰҕ^עzۉyҪПoOMд

              wע֪߼rʾۃ׵κΰY磺ʹ۾t[ηҕģҕWĤÓxκΰY

              ÿƿעҺHچۆδί

              ÿƿעҺкеĄ]ʹÄ2 mg գƿеĿɳȡwe100 ΢ȫע֮ǰųҺwעƿȫҺwˎ^ƄԌcˎһͬų˕rAĈAwcעϵĺɫoˎRஔ50΢2 mgգ

              ע֮횁GκδʹõĮaƷ

              Pڽoˎǰˎ̎ԔҊע헡

              ƿʹf

              1. ȡwƿӵzⲿM

              2. ṩ 18 G5 ΢^V^B 1ml o^ע

              3. ^V^뵽ƿzλֱ^ȫMƿвҼ˵_ƿӵײײ߅

              4. ohƷƿеЃ뵽עƿ̎λ΢AбԱȫ˷ֹM_^V^бǽ]Һwڳ^бƿӃAб_^V^б ]Һw

              5. ƿӳՕr_Uֳȫſ^V^

              6. ȡ^V^ǡ̎ ע^V^ڲwע

              7. ʹßog 30 G x ½ Ӣע^ι̰bע

              8. עc^zעǷККָpp ôעֱ픲

              9. ppUųКͬrų^Ʒ@r^cעϘӛ 0.05 ml Ŀ̶ȌR

              10. ÿƿHδʹҪίʹһƿµעҺ Ҍڽo豾Ʒ֮ǰҪQo^עg_ ^Vע ծطҎ̎κδʹõˎU

              Ų
              ȫY

              8 III RоӋ 3,102 λ߽M˰ȫȺ2,501 λ߽˱Ʒ]2 mgί

              wע䱾ƷrFcעPо۲زl ʲ 1/1,900@ЩزäۃҕWĤÓx԰׃ ׃wѪwÓxۃȉߣԔҊע헡

              ҊIJڽܱƷίĻlٞ 5%YĤ Ѫ25%ҕ½11%ʹ10%׃ϣ8%ۃȉߣ8% wÓx7%wwY7%

              б

              ȫԔԴ 8 III RоmYѪܣԣnAMD gPS׃ԣCRVOҕWĤo}BRVOҕWĤ֧o}DMESˮ[ mCNVԽҕ^l}jĤѪܣ cעˎНPϵв

              ϵy##ٷlг˲lʵĶx£

              dzҊ1/10Ҋ1/100<1/10Ҋ1/1,000<1/100 Ҋ1/10,000<1/1,000

              ÿlʽMՇس̶ȵĸߵˎﲻ

              1III Rԇ򞣨mY nAMD DME III RԇĺϲкOygίgFˎﲻ 

               

              *ԓ֪cѪܣԣnAMD PHѪܣԣnAMD о^쵽

              **Bۃ׺BۃкOygЇۃװYĈ

              *** кOyAΈijƤWnԼeć ^/^ӷ

              x

              gP AMD III RоܿѪ˨ˎίĻ߽YĤİlοίĻߺͽܱƷίĻ֮glʵஔ

              }Ѫ˨˨¼ATEscȫ VEGF ƴڝPԵIJ¼wע VEGF ƄՓϴڰlмļȄ}Ѫ˨˨¼LU

              nAMDDME ȶ۵׼ȺRԇ^쵽Ą}Ѫ˨˨¼İl^ڸmYоսMcսM֮gδҊ@ ĽMg

              ͬеίԵ|ˎһܱƷίĻНڳFĿ

              Žɡ
              ԳɷݰջƷһo^

              Ի۲ܸȾ

              صĻۃװY

              ע헡
              cwעPķ

              wעwע䱾ƷۃۃװYԴҕWĤÓxҕWĤԼtԴ԰׃ϣԔҊʹ ñƷrʼKʹúϸğoע似gעһ܃ȑMбOyԱڳFȾr܉oίָڳFκʾۃ׵İYҕWĤÓxκ¼r¼rMЈ

              ۃȉ

              wע 60 犃wע䱾Ʒ^쵽ۃȉߣԔҊЈ^ͲwȽoѪ܃ƤLӣVEGFƄۃȉmۿƲѵĻҪȡAʩۃȉڵ 30 mmHg rע䱾Ʒr횱Oyۃȉҕ^ѪעMǡ̎

              ԭ

              ίõ|ˎƷНڵԭԣԔҊ III RԇίǰƷM߷lʾs 1% 3%o豾Ʒ24-100 еıƷwzҲПoՓПo߷ƷįЧȫԟoӰ֪߈ۃ׵κwY磺ʹηlt@^Rw

              ȫ

              вwעVEGFƄ֮Fȫ¼Ĉ۲Ѫ̈́}Ѫ˨˨¼}Ѫ˨˨¼xļѪԭѪܣԣnAMDоϲƷίMڵһѪ˨˨¼lʞ1.8%32/1824λߣDMEоĻ52ܱƷ“ίMߵĄ}Ѫ˨˨¼lʞ3.3% 578е19սM2.8%287е8Ļ100ܱƷ“ίMߵĄ}Ѫ˨˨¼lʞ6.4%578е37սM4.2%287е12Փ@Щ¼cVEGFP^ȥ6 L̕XȱѪlļDMEʹñƷİȫԔˌ@Щߵί֔

              ᘌѪܣԣnAMDDME wȿ-VEGF ίrmԣ

              • ʹñƷMpͬrίİȫԺЧδMϵyоԔҊ Rԇ򞡿ͬrMpίܕȫ¶Ķпȫ¼LU

              • ϲʹ VEGFѪ܃ƤLӣaƷ • ПoƷc VEGF aƷȫ۲ϲʹ÷Ĕ

              • ѪܣԣnAMD Mп VEGF ί֮clҕWĤɫƤ˺PLUذeĺ/߶¡ҕWĤɫƤÓx@ЩҕWĤɫƤ˺LUصĻʹñƷίr֔

              • ڿԴҕWĤÓx߻ 3 ڻ 4 Sѿ׻ܽ^oί

              • FҕWĤѿtͣoˎֻѿ׵õޏ֮󷽿ɻ֏ί

              • Ftͣoˎһ֏ίĕrgA´νoˎrg

              o cҕĩuѳCҕBCVA½30 ĸ

              o ۼİҕWĤ³Ѫ߳Ѫeռ׃e 50%

              • шлӋۃgtgǰ 28 ȕͣoˎ

              • ƷڋDŮǝڵī@泬^ˌ̥ĝLUԔҊЋDڋDŮˎ

              • gڋDŮڳνoˎǰίgԼĩβwע䰢պ 3 ƒȱʹЧıзʽԔҊЋD ڋDŮˎ

              HίĻ

              ʹñƷǻѪtףHbA1c^12%ֳҕWĤ׃򲡻߻I򲡌µDMEMίĽ

              δʹñƷȫȾҕWĤÓxSѿ׵ĻMPоδѪMЧƵ򲡻ПoʹñƷίĔtڌMίr]ȱʹñƷPϢ

              {ʹÙCӰ

              ڿܴcע۾zPĕrҕXϵKע䱾ƷɌ{ʹÙCap΢Ӱҕܫ@óֻ֏֮ǰ߲{ʹÙC

              ̎ú̎ע

              ÿƿעҺHۆδʹ

              ƿעҺ100 ΢^]50 ΢ڽoˎǰ회Һwŵ

              oˎ֮ǰĿzҺǷκή/׃ɫ^Ƿκθ׃^쵽κθ׃tñˎ

              ʹ 30G x½Ӣ^Mвwע

              ЋDڋDŮˎ
              gڋDŮ

              gڋDŮڳνoˎǰίgԼĩβwע䰢պ 3 ƒȱʹЧıзʽԔҊע헡

              ˎ

              ПoڋDŮʹðյĔ

              оƷ̥-̥жԣԔҊˎ

              M۲oˎȫ¶OڃȲʹñƷǝڵī@ڌ̥aĝLU

              ڋDŮ

              вǷĸųˎڋ׃aLUĿ

              ]ڃʹñƷĸιBͯī@ԼίĸHī@QДಸ߀ǷŗƷί

              ֳ

              ȫ߱¶ĄоYտɓpԺʹֳԔҊˎȫ¶O͵۲oˎAӋoˎ󲻕FԓЧ

              Ńͯˎ
              δڃͯд_ƷİȫԺͯЧδڻѪܣԣnAMD DME ăȺʹ^Ʒ

              ˎ
              RоSCܱƷίĻ߼s 76%20492701 65 q s 46%1250 / 2701 75 q@ЩоSgLЧȫԷo@

              ˎo⿼]75 qSˮ[DMEȺʹñƷĽ

              ˎ໥á
              δ_չ໥о

              δоS沴ҹPDTͱƷ“ίδ_ȫ

              ȱоYԓˎﲻcκˎʹ

              ˎ^
              Rԇʹÿ½oˎ 4 mger³ˎ 8 mg

              עweӵˎ^ʹۃȉڰlˎ^rOyۃȉtJбҪtMгί

              Rԇ򞡿
              RЧԺͰȫ

              ѪܣԣnAMD

              ѪܣԣnAMD _չăSCpäԌоVIEW1 VIEW2ЌƷЧԺͰȫMu 2,412 λ߽ίMЧurƷM1,817 λg 49-99 ܚqƽg 76 ܚqڴRоSCŽܱƷίg^ 65 ܚqϵıs 89%1,616/1,81775 ܚqϵĻ߱t s 63%1,139/1,817ÿһо 1:1:1:1 ıSC 4 oˎMһM

              1Ʒ 2 mg ÿһBm֮ÿ 8 ܽoˎһΣƷ 2Q8

              2Ʒ 2 mg ÿ 4 һΣƷ 2Q4

              3Ʒ 0.5 mg ÿ 4 һΣƷ 0.5Q4

              4ο 0.5 mg ÿ 4 һΣο 0.5Q4

              оĵڶ^mSCŵίίҕͽʌWYuoˎrgM{Aoˎg 12 

              ڃоҪЧKcϷҕԱ֣ 52 rҕ^ڻĽС 15 ĸĻ߱

              VIEW1 о 52 ܕr95.1%ıƷ 2Q8 MҕõS ֮ο 0.5Q4 Mı 94.4%

              VIEW2 о 52 ܕr95.6%ıƷ 2Q8 MҕõS ֮ο 0.5Q4 Mı 94.4%оcο 0.5Q4 MƷίзЧԲҾRЧ

              оϲԔYҊ 2 ͈D 1

              2 52 ܣҪKc͵ 96 ܵįЧYVIEW1 VIEW2 о Bĺϲ

              ABCVA:ѳCҕ

              ETDRS:ҕWĤ׃ίо

              LSANCOVAģ͵õС˾

              PPSϷ

              BзʹȫFASĩ^YDLOCF·⣺52ܕrSҕĻ߱˷ϷPPS

              C)ֵ鱾ƷMֵpȥοMֵֵʾڱƷ

              Dͨ^BӋŅ^gCl

              Eί_ʼÿ½oˎһβoˎΣ֮

              FŅ^gȫ-10%@Ʒο

              D 1. VIEW1 VIEW2 оҕ׃ƽֵ 96 cֵ֮gı^

              VIEW1 VIEW2 оѽCʹñƷ܉ʹAҪЧKcۿоҕX܆{飨NEI VFQ-25FRxĸ׃ڻֵ^οĽMg]_Rx׃ij̶cѰlоYѳCҕBCVA 15 ĸ

              оĵڶ^쵽ˎЧͨ܉Sֵ 96 ĩurÿ¶MעίĻ߱ 2-4%ҪoˎrggHһ·һעίĻ֮߱һ

              ڃоЄMƽ CNV e@½

              ÿоԼڅRпurM磺gԄeNҕ׃׃įЧYcȺĽYһ

              о 13406SIGHTİȫԺЧ

              һSCpäԌоSIGHTu˽ܱƷίnAMDЇߵİȫԺЧԣSIGHTԓо304߽ίҿMЧur228ܱƷί50q88q֮gƽg65qڱо߰3:1 ıSCMƷίMWPDTƷίM

              1ƷίMȽ3αƷ 2 mgעÿһ˺ 2 mgעÿ8һ

              2PDTƷίMrһPDTίڵ28֮ǰR`оߵRДٽoPDTί˺ԇڵ2832364048ܕrܱƷ2 mgע

              ҪЧԽKcǵ28ETDRSyõBCVA^ƽ׃cPDTƷίMƷίMԇߵBCVA28cȵƽƷȸ󣨱ƷM14.0ĸ vs PDTƷM3.9ĸgIJ@ԷC˱ƷίPDTίăЧ

              ƷίMԇоǰȌFBCVAڻĸһֱSֵоPDTƷίMоǰBCVAFmȸںԇߏPDTίñƷίBCVAF@52BCVA ڻ׃ֱ֧ƷίMPDTƷίMƷM15.2ĸ vs PDTƷM8.9ĸ

              BCVAڻƽ׃ҊD2

              D2ڻBCVAƽ׃ĸ

              VIEW1 VIEW2 оѽCʹñƷ܉ʹAҪЧKcۿоҕX܆{飨NEI VFQ-25FRxĸ׃ڻֵ^οĽMg]_Rx׃ij̶cѰlоYѳCҕBCVA 15 ĸ

              оĵڶ^쵽ˎЧͨ܉Sֵ 96 ĩurÿ¶MעίĻ߱ 2-4%ҪoˎrggHһ·һעίĻ֮߱һ

              ڃоЄMƽ CNV e@½

              ÿоԼڅRпurM磺gԄeNҕ׃׃įЧYcȺĽYһ

              о 13406SIGHTİȫԺЧ

              һSCpäԌоSIGHTu˽ܱƷίnAMDЇߵİȫԺЧԣSIGHTԓо304߽ίҿMЧur228ܱƷί50q88q֮gƽg65qڱо߰3:1 ıSCMƷίMWPDTƷίM

              1ƷίMȽ3αƷ 2 mgעÿһ˺ 2 mgעÿ8һ

              2PDTƷίMrһPDTίڵ28֮ǰR`оߵRДٽoPDTί˺ԇڵ2832364048ܕrܱƷ2 mgע

              ҪЧԽKcǵ28ETDRSyõBCVA^ƽ׃cPDTƷίMƷίMԇߵBCVA28cȵƽƷȸ󣨱ƷM14.0ĸ vs PDTƷM3.9ĸgIJ@ԷC˱ƷίPDTίăЧ

              ƷίMԇоǰȌFBCVAڻĸһֱSֵоPDTƷίMоǰBCVAFmȸںԇߏPDTίñƷίBCVAF@52BCVA ڻ׃ֱ֧ƷίMPDTƷίMƷM15.2ĸ vs PDTƷM8.9ĸ

              BCVAڻƽ׃ҊD2

              D2ڻBCVAƽ׃ĸ

              CRTCNVYcBCVAYһƷίM28ܕr^쵽@@Щһֱֵ52PDTƷίM28ܕr^쵽p΢ڸñƷί^쵽@ 28ܺ͵52ܕrCRTCNVƽ׃Ҋ3

              328ܺ͵52ܕrCRTCNVƽ׃

               

              52 ܕrĹܺΑBWYֱ֧ƷίM PDTƷίM@چӱƷί̎^톢ӱƷί

              SIGHTобFİȫcPIоVIEW1 VIEW2

              Sˮ[DME

              Sˮ[ҕWĤ׃ĺԱFѪͨ͸߲ҕWĤëѪܓp@܌ҕʧ

              ܱƷίĻУ II 򲡻ߞ_ʼίܿ^쵽ΑBWҕWĤ[CRT]DRSS ˮƽķ

              VIVIDDMEcVISTADMEо֮ƷMڵ52ܵҕWĤ^ƽpڽyӋW@ڼMбƷ 2Q8M-192.4m-183.1mսMtքe-66.2m-73.3mVIVIDDMEcVISTADMEоĵ100Ʒ 2Q8Mֵ½քe-195.8m-191.1mսMtքe-85.7m-83.9m

              ҕWĤ׃س̶DRSSƲڃɼrͨ^VIVIDDMEVISTADMEоAOķʽMuоVIVIDDMEcVISTADME DRSSuֿɷּĻ߱քe73.7%98.3%о52Ʒ2Q8M_DRSSuָƲڃɼĻ߱քe27.7%29.1%սMĻ߱tքe7.5%14.3%ڵ100Ʒ2Q8MĻ߰ٷ֔քe32.6%37.1%սMtքe8.2%15.6%

              RЧԺͰȫ

              Sˮ[DME

              DME _չăSCpäԌоVIVIDDME VISTADMEЌƷЧԺͰȫMu 862 λ^ίĻߣƷM576 λϯЧuҪg 23 87 ܚqƽg 63 ܚq DME оSCŵƷίg^ 65 ܚqϵĻ߱s 47%268/576g_ 75 ܚqϵĻ߱s 9%52/576о߶໼ II ڃо 1:1:1 ıSC 3 MһM

              1ÿ½o 2 mg ƷһβBmo 5 ֮ÿ 8 עһΣƷ 2Q8

              2ÿ 4 ܽo 2 mg ƷһΣƷ 2Q4

              3S߼gԌգ

              ĵ 24 _ʼҕ׃AֵĻYܸίƷίMĻ߿ɽܼίսMĻ߿ɽܱƷί

              ڃоҪЧKc 52 ܕr BCVA ^׃ľֵоCƷ 2Q8 McƷ 2Q4 MĽMg_˽yӋW@ˮƽұȌսMЃԓ@ɳmо 100 

              VIVIDDME c VISTADME оķYԔı 4 ͈D 3 ʾ

              4VIVIDDME VISTADME ое 52 ܺ͵ 100 ܣȫʹ LOCFrįЧY

               

                A ί_ʼÿעһע 5 Σ֮

              B LS CI ANCOVA ģӋԓģ͌ BCVA yֵһf׃ίMһ VIVIDDME ؅^W/Ĵcձһ VISTADME Ќ MI / CVA ʷһ

              C ֵڱƷMpȥԌգ⣩M

              D ʹ Mantel-Haenszel ә෽ʽڵ؅^W/Ĵcձ VIVIDDME ԣ MI CVA ʷ VISTADME ԣ MУĶӋŅ^gCIMнyӋWz

              E BCVAѳCҕ

              ETDRSҕWĤ׃ίо

              LOCFĩ^YD

              LSС˾Դ ANCOVA

              CIŅ^g

              D 3VIVIDDME VISTADME ол 100 ܵ BCVA ׃ƽֵͨ^ ETDRS ĸu

              u

              ÿоԼںϲпurM磺gԄeNǻѪtףHbA1cҕ-VEGF ίįЧYcȺĽYһ

              VIVIDDME VISTADME оքe 369% 19743%λ߼˿-VEGF ίϴÓڞ 3 »L VEGF ƄίĻ߁MίЧcδ VEGF ƄĻ

              ȿtuJбҪpۼĻ䌦ҲԽܿ-VEGF ί VISTADME о 100 оڃȵ 21770.7%ƷίMp۾˱Ʒע VIVIDDME о9735.8%ƷίM䌦۽һN-VEGF ί

              һ헪^Rԇ򞣨DRCR.net Tвˇ OCT ҕΘ˜ʞAίˎڵ 52 ƷίMn224˷ίĽYƽעΔ 9.2 ԓYc VIVIDDMEоc VISTADME обƷ 2Q8 MܽoˎΔо T бƷίM^쵽ĿwˎЧcоо^쵽ıƷ 2Q8 Mஔо T ƽҕ 13.3 ĸҕ_ 15 ĸĻ߱t 42%VIVIDDME оc VISTADME о۲ȫȫԽY ATEs ¼

              о 15161VIVID-EASTİȫԺЧ

              һ헶SCpäԌоu˱ƷίЇSˮ[DMEߵİȫԺЧԣVIVID EAST378߽ίҿMЧԷ80%Їˣ301/37824q81q֮gƽg58qcVIVIDDMEVISTADMEһо1:1:1ıSCM3ίMеһ

              ҪЧ׃52BCVAETDRSĸu֣cȵ׃ЇƷ 2Q8ͱƷ 2Q4 ίMFƃڌսMҾнyӋWxƷ 2Q8M12.7ĸvs Ʒ 2Q4M14.4ĸvsսM-0.3ĸ ҕͽʌWKcԼԷһ֧ԓYՓ

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              VIVID-EASTобFİȫ͇PIоVIVIDDME VISTADME

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              Ѫ܃ƤL-AVEGF-ḀPLӣPlGFѪVEGF ɆTǃƤĴнzڅӺѪͨ͸

              VEGF ͨ^Ƥ VEGFR-1 VEGFR-2 ɷNҰἤøwl]PlGF Hc VEGFR-1 YVEGFR-1 ڰ׼ı_VEGF-A @Щw ^ȼ²ѪγɺѪͨ͸һNc VEGF-APlGF YϵĿT_wƃԴ VEGF wc VEGF-A PlGF ĽYϺͼ

              о

              ﲣwעo谢 2 4mg/ۄǼ׺ƤҊg͝δҊNOAEL 0.5mg/ԓ°յϵy¶AUCs˲wעoˎ 2mg ϵy¶ 56 Rо δҊƲ

              z

              δMаյzԇ

              ֳ

              һ헞 6 µĺo}oˎԇu˰ՌԺʹӰÿܽoˎһoˎ 3-30mg/kgнoˎ¾ҊcԼˮƽ׃Pͣ½{ԾҊΑB;ӻ׃߀ҊѳӌmԼSSwlͳݜp@Щ׃ӌmꎵήsYPͣˎ 20 ܃и׃ ɻ֏̈́ 3mg/kg µxյϵy¶AUCs˲wעoˎ 2mg ϵy¶ 1500 ԓԇδ NOAEL

              ڃ̥-̥аlԇ##γÿ 3 o}עo谢ա3mg/kg ÿ 6 Ƥעo谢ա0.1mg/kg ɮḁ- ̥аl̥-̥жԷҪGʧʺ̥лΰˮ[Ěȱֺc]iXKʹѪȱpΣ׵عǺ߹ںߺ׵ǻȫ@Щԇĸw NOAEL 3mg/kgЄ¾Ɍ̥лδҵ̥-̥аlԵ NOAELЮḁ-̥жԵ̈́0.1mg/kgµxյϵy¶AUCs˲ wעoˎ 2mg ϵy¶ 6 

              °

              δMаյ°ԇ

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              wע۲ղMwѭhҪԷğoԵďͺc VEGF YϣʽwѭhȻֻСxա܉cԴ VEGF Y

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              15060 ţۃעҺ ۃעҺ ‡Vetter Pharma-Fertigung GmbH & Co. KG 40mg/ml(һʹ^V^)*1֧/ 4800Ԫ

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              2. ˎƷrHHrˎֵԓܴMԒ400-6000-838Mԃֱ“ϵ҂

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